About 5% to 10% of all cancers are due to inherited (genetic) damage to genetic material (DNA) which is inherited from the parents. These lesions are called inherited mutations. Hereditary Breast Cancer and Hereditary ovarian cancer are due, to the higher rate, to lesions in genes BRCA1 (~ 50%) or gene BRCA2 (~ 35%).

Male carriers of mutations in BRCA2 have an 8% risk of developing breast cancer and 20% risk of prostate cancer by the age of 80. A smaller percentage of cases is due to alterations of genes RAD51C (1.5-4%), PALB2 (~ 3.4% ) and CHECK2 (~ 2.2%). The probability of mutation transfer from parent to each child is 50%. For the Greek population it has been recorded and published a range of pathogenic mutations in the genes BRCA1 and BRCA2.

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